https://www.ceesdekker.net - An Overview

Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions contain:

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Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

2010, designed a completely new way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-point out nanopores

Microbiology has only existed for just a century, since we started to research micro-organisms a lot more significantly. I believed nanobiology was an ideal time period, for the reason that all molecular Organic relevant interactions take place at the nanoscale: a protein is a handful of nanometres in measurement, DNA is 2 nm thick.’

A lot of linked developments followed, where our team recognized distinctive transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into tiny proof-of-theory electronic circuits.

Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation

In 1993, like a youthful and keen associate professor at Delft University of Technological know-how, I had originally centered the research attempts of my team on measuring the electrical conductance of only one conducting-polymer molecule. Inside two several years, we experienced created a device through which only one wire of the phthalocyaninepolysiloxane polymer was connected among two carefully spaced metallic nanoelectrodes.

Resolving the stage measurement in condensin-pushed DNA loop extrusion identifies ATP binding given that the step-producing approach

‘The idea that There is certainly this type of detail as being a starting, a huge bang, is now an interesting signpost to take into account that there was a creator. But additional generally, and on the basis of pure ceesdekker rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: essentially, there are actually only atoms and natural forces that we are able to evaluate.

2006, first demonstration of molecular sorting within a lab with a chip utilizing biomotors; discovery of nanobubbles in stable-state nanopores; and very first estimate of electrokinetic Electricity conversion inside a nanofluidic channel

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes

The biophysicist from Delft – who has long been One of the more cited experts from the Netherlands For several years – normally takes his duty to contribute to the rationalization and popularisation of his do the job for the border of physics and biology really significantly and frequently seems from the media; if not to discuss his work, then about the connection amongst science and his Christian faith.